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Duratia 60 mg, which contains the active ingredient Dapoxetine, is primarily used to treat premature ejaculation (PE) in men. Here are some situations when you should avoid taking Duratia 60 mg or use it with caution:

1. Allergic Reaction: If you have a known allergy or hypersensitivity to Dapoxetine or any other ingredients in Duratia 60 mg, you should avoid taking this medication. Allergic reactions can range from mild skin rashes to severe reactions requiring immediate medical attention.

2. Severe Liver or Kidney Impairment: Duratia 60 mg should be used with caution in individuals with severe liver or kidney impairment. Dapoxetine is metabolized in the liver and excreted via the kidneys, so impaired function of these organs can affect the clearance of the medication from the body.

3. Use with Certain Medications: Duratia 60 mg can interact with other medications, especially those that affect serotonin levels in the brain or those metabolized by the same liver enzymes. Avoid concurrent use with monoamine oxidase inhibitors (MAOIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and certain antibiotics and antifungal medications. Always inform your healthcare provider about all medications you are taking before starting Duratia 60 mg.

4. Cardiovascular Conditions: Dapoxetine can cause changes in blood pressure and heart rate. If you have a history of cardiovascular disease, including heart rhythm disorders, or if you are currently taking medications for heart conditions, use Duratia 60 mg with caution and under the guidance of a healthcare provider.

5. History of Seizures: Dapoxetine has been associated with a small risk of seizures. If you have a history of seizures or epilepsy, discuss the risks and benefits of using Duratia 60 mg with your healthcare provider before starting treatment.

6. Alcohol Consumption: Avoid consuming alcohol while taking Duratia 60 mg. Alcohol can increase the risk of side effects such as dizziness, drowsiness, and impaired judgment, potentially leading to accidents or injuries.

7. Pregnancy and Breastfeeding: Duratia 60 mg is not indicated for use in women. It should not be used during pregnancy or breastfeeding due to potential risks to the fetus or nursing infant.

8. Age Considerations: Duratia 60 mg is typically not recommended for use in individuals under 18 years of age or over 65 years of age, as its safety and effectiveness in these age groups have not been established.

Always consult with a healthcare provider before starting Duratia 60 mg or any medication for premature ejaculation. They can evaluate your medical history, current medications, and overall health condition to determine if Duratia 60 mg is appropriate for you and provide guidance on safe and effective use.