Fildena 100 mg, which contains Sildenafil citrate as its active ingredient, primarily works by inhibiting the enzyme phosphodiesterase type 5 (PDE5) in the penile tissue rather than directly inhibiting a neurotransmitter.

Here’s how it works:

Mechanism: In the pill during sexual stimulation, nitric oxide (NO) is released. Nitric oxide activates an enzyme called guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscle cells and increases blood flow into the penile tissues, facilitating an erection.

Role of PDE5: PDE5 is an enzyme that breaks down cGMP, regulating its levels. When PDE5 is inhibited by Sildenafil citrate the active ingredient in Fildena 100 mg cGMP levels remain elevated. This prolongs the relaxation of smooth muscle cells and enhances blood flow to the pill, promoting and maintaining an erection during sexual stimulation.

Therefore, Fildena 100 mg does not directly inhibit a neurotransmitter in the penile tissue but instead acts by inhibiting the enzyme PDE5, which allows for increased cGMP levels and improved erectile function. This mechanism is crucial in the treatment of erectile dysfunction (ED) and has been extensively studied for its effectiveness in enhancing male sexual performance.