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Megalis 20 mg is a medication used for erectile dysfunction, containing the active ingredient Tadalafil. Typically, it's recommended to take Megalis (or any Tadalafil medication) approximately 30 minutes before sexual activity. However, it can be effective for up to 36 hours after ingestion, so you have a window of time to work with. Always follow the advice of your healthcare provider or the instructions provided with the medication for the most accurate guidance tailored to your specific needs.